The Cytotoxicity of Some Biologically Active Nano Compounds against Colon Cancer: Advanced Biochemical Analyses

Abdou Saad El-Tabl; Ashraf Abd El Raouf  Dawood; Sherif  Kolkaila; Esraa Hisham Mohamed; Ahmed Ashour

Autori

Abdou Saad El-Tabl Department of Chemistry, Faculty of Science, Menoufia University, Shebin El -Kom, Egypt
Ashraf Abd El Raouf Dawood Department of Biochemistry, Faculty of Medicine, Menoufia University, Shebin El -Kom, Egypt
Sherif Kolkaila Department of Chemistry, Faculty of Science, Damanhour University, Damanhour, Egypt
Esraa Hisham Mohamed Department of Chemistry, Faculty of Science, Menoufia University, Shebin El -Kom, Egypt
Ahmed Ashour Department of Chemistry, Faculty of Science, Menoufia University, Shebin El -Kom, Egypt

Cuvinte cheie:

Colorectal cancer, Cytotoxicity, Mutagenic potential, HCT-116 cell lines and molecular docking

Rezumat

Colorectal cancer is one of the most common cancers worldwide, and it is also one of the major causes of mortality from cancer. Chemotherapy drugs are generally limited due to various complications, as well as the development of resistance and recurrence. This study determined the selective cytotoxicity and mutagenic potential of five novel metallo-organic complexes nanoparticles against colon cancer cell line (HCT-116). The complexes have been prepared and then their structures were characterized by some instrumental analyses. The electron microscope data confirmed the Nano form of these complexes. In vitro antitumor activity of the complexes had been studied against colon cancer cell lines and the IC₅₀ values were detected. The cytotoxicity studies of the complexes showed that, the complexes have no side effects after completing the experiment period (6 weeks). The more effective and probable binding modes between the studied metal complexes NPs with different active sites of Colorectal cancer were investigated using molecular docking studies. The results augur well for colorectal cancer treatment.