Synthesis, Spectroscopic Studies, Thermal Analysis and Molecular Docking of Chloramphenicol Metal Complexes as Anti-Prostate Cancer

Abstract

Chloramphenicol metal complexes were synthesized, and examined utilizing IR, UV-Vis, ESR, magnetic susceptibility, and thermal analyses (TGA and DTA). Chloramphenicol complexes have a 1:2 (M:L) stoichiometry. According to IR data Chloramphenicol coordinates to metal ions as a bidentate ligand attached to the oxygen atom of hydroxyl groups. All complexes have octahedral geometry, according to magnetic moment values and electronic absorption spectra. Cu(chloramphenicol)₂(H₂O)₂ ESR measurements revealed isotropic spectrum. For the purpose of determining the decomposition mechanism and stability ranges, thermal studies of the ligands and their metal complexes were performed. Calculations are made for the thermodynamic parameters (E*), (H*), and (S*). A number of metal complexes of chloramphenicol were tested for their antimicrobial properties. The copper complex medication is molecularly docked with 6XXO prostate cancer protein.