Novel Metal Complexes of Bioactive Amide Ligands as New Potential Antibreast Cancer Agents

Abstract

New binary Cu(II), Mn(II), Ag(I), Fe(III), Co(II), Ni(II), Zn(II) ,Cd(II), Mg(II), Al(III) and Ca(II) metal complexes derived from (Z)-N'-(2-hydroxybenzylidene)-2-((Z)-(2-hydroxybenzylidene)amino)pro p-anehydrazide ligand were prepared. Physicochemical studies (IR, UV - Vis, Mass, 1H-NMR, Magnetism , DTA and TGA, conductivity and ESR) were carried out. The measurements revealed that, the ligand coordinated to the metal ion in a neutral hexadentate or dibasic hexadentate mode through nitrogen atoms of imino group and oxygen atom of the hydroxyl group in protonated or non-protonated form. All metal complexes are non-electrolytic in nature as suggested by molar conductance measurements. The complexes are adopted to be tetragonal distorted octahedral geometry around the metal ions. The cytotoxic activity of the ligand as well as some of its metal complexes was evaluated against breast cancer (MCF-7). It is worth noting, the cytotoxic activity was enhanced upon complexation. Also, it was interestingly found that, Zn(II) complex (7) recorded the highest IC50 value against MCF-7. However, the other tested complexes showed a weak cytotoxicity against the same cell line compared with a standard drug (vinblastine sulfate).The molecular docking of the tested.