Physicochemical Characterization, Thermal Analysis, Biological Studies and Molecular Docking Studies of Cefoperazone Complexes as Anti-Breast Cancer

Rezumat

The synthesis, physicochemical characterization, and thermal analysis of cefoperazone with transition metals (Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II), and Hg(II) are investigated. Cefoperazone is found to serve as a bidentate ligand.  From magnetic measurements and spectral data, octahedral structures were hypothesized for all complexes except Ni, Cu, and Hg, which possessed tetrahedral structures. TGA and DTA were used to suggest thermal degradation pathways for prepared compounds. The thermal breakdown resulted in the creation of metal oxides and carbon residue as a final product. Molecular docking studies of some complexes as anti-breast cancer.