Preparation and Characterization, 99mTc-Taurine Complex as a Novel SPECT Cancer Imaging Agent

Abstract

Cancer remains a main cause of world mortality, with early detection being crucial for powerful treatment and stepped forward affected person effects. This study focuses on the preparation and characterization of technetium-taurine complex, specifically ^99mTc-taurine, as radiopharmaceutical with high cancer imaging potential. The goal was to synthesize the complex, determine its structure. The complex characterized by infrared (IR) spectroscopy, proton nuclear magnetic resonance (¹H NMR), liquid chromatography–mass spectrometry (LC-MS), and high-performance liquid chromatography (HPLC), all of which confirmed the formation of the complex. Molecular docking study is done for Taurine and Tc-Taurine showed that Both Taurine and Tc-Taurine Complex show binding affinity to aromatase (3S7S). and Tc-Taurine complex could be explored for SPECT imaging in breast cancer, particularly for detecting aromatase (3S7S)-expressing tumors.