Evaluation of the Antiviral Activity of Rosemary Extracts against Respiratory Syncytial Virus (RSV)

Abstract

The search for novel antiviral marketers from traditional medicinal flora is ongoing. Rosemary (Rosmarinus officinalis L), a extensively used herb, has been investigated for its capacity antiviral homes. This study objectives to assess the antiviral pastime of methanol and aqueous extracts of rosemary towards respiration syncytial virus (RSV) and evaluate their efficacy with ribavirin, a fashionable antiviral agent. Methanol and aqueous extracts of rosemary have been tested in vitro for antiviral interest in opposition to RSV the usage of an XTT-based colorimetric assay. The antiviral activity was quantified by determining the 50% effective concentration (EC50) required to achieve 50% cytoprotection against RSV infection. The selectivity index (SI), calculated because the ratio of 50% mobile cytotoxicity attention (CC50) to EC50, became used to assess the safety and efficacy of the extracts. Ribavirin served as a nice manage for contrast. The methanol extract of rosemary exhibited an EC50 of 0.320 µg/ml and a SI of 250.00, indicating superior antiviral activity with minimal cytotoxicity as compared to ribavirin, which had an EC50 of 4.19 µg/ml and an SI of 27.92. The aqueous extract demonstrated an EC50 of 1.150 µg/ml and an SI of 55.00, suggesting some antiviral potential, though less potent than the methanol extract.