Study on Acute Dermal Irritation of Mangiferin Hydrogel in Rabbits

Rezumat

The evaluation of the skin irritation potential of the new compound is essential to ensure the human's safety. In this study, the acute dermal irritation potential of Mangiferin hydrogel was investigated in rabbits following the Organization for Economic Cooperation and Development guidelines (OECD 404).  During the skin irritation test, the Mangiferin hydrogel was applied to the rabbit skin, and the test site was monitored at different time intervals (1 hour, 4 hours, 24 hours, 72 hours, and thereafter for up to 14 days). Throughout the study, no dermal responses such as erythema or edema were observed. Based on these results, Mangiferin hydrogel does not produce any dermal irritation and appears to be safe for topical use.