Evaluation of Dermal Irritation and Skin Sensitization of Icaritin in Rabbits

Abstract

The cutaneous irritation and skin sensitization toxicity potential of a novel molecule, Icaritin (ICT) loaded scaffold, was investigated in rabbits by the guidelines established by the Organization for Economic Cooperation and Development (OECD). Rabbits were dermally connected to an ICT-loaded scaffold for 72 hours or repeated application to evaluate the level of dermal irritation. During the test, there were no instances of adverse responses such as erythema or oedema that were seen, as shown by the data. The skin sensitization test was performed on rabbits, and they were exposed to ICT laden scaffold for twenty-four hours. It was discovered that the ICT-loaded scaffold did not exhibit any sensitization response, however, the positive group exhibited a significant amount of sensitization symptoms. The results of this study indicate that the scaffold loaded with ICT does not result in cutaneous irritation or skin sensitization toxicity, and it seems to be safe for usage on animals.