Biochemical Studies on Some Novel Organometallic Complexes as Anti-Human Prostate Cancer

Abstract

This study determined the selective cytotoxicity and mutagenic potential of five Schiff base complexes nanoparticles of copper salt against prostate cancer cell line (PC-3). The electron microscope data confirmed the Nano form of these complexes. Invitro antitumor activity of the complexes had been studied against breast cancer cell lines and the IC₅₀ values were detected. The invivo cytotoxicity of the complexes showed that, the complexes have no side effects after six weeks was confirmed by some clinical studies. The more effective and probable binding modes between the studied metal complexes NPs with different active sites of prostate cancer were investigated using molecular docking studies. The results augur well for prostate cancer treatment. It was found that the complex nanoparticles under study can interact with antioxidant to form cancer-specific proteasome inhibitors and apoptosis inducers in prostate cancer cell.