Relationship of Interleukin 2 and 4 Levels in Moderate and Severe Hemophilia Patients with Arthropathy

Abstract

Background: Hemophilia is a hereditary bleeding disease that can cause haemarthrosis, which can then progress to chronic arthropathy in those who have the most severe types of the disease. It can result in a significant degree of disability and negatively impact a patient's quality of life.

Aim: study the relationship of Interleukin 2 and 4 levels with development of chronic arthropathy in moderate and severe Hemophilia patients.

Method: has been carried out the assays on patients with hemophilia in the Center of Hematology at Al-Karama teaching hospital, Waist University. 50 patients were involved in this study with ages ranging from (3-45) years. 16 of them were diagnosed as hemophilia moderate, while 34 were hemophilia severe.25 healthy subjects with matched age were involved as a control group.

Results: revealed this study the interleukin (2 and 4) levels in Hemophilia patients are significantly higher (22.3 ± 7.9 and 11.4±3.2) pg/ml respectively at (p < 0.05) when they are compare with control values (1.8 ± 0.5 and 1.6±0.7) pg/ml.

Conclusions: values increasing of interleukin 2 or 4, can used as biomarker indications for development of chronic arthropathy in moderate and severe Hemophilia patients.