Fabrication of Tamarindus indica Seed and Basella alba Seed Mucilage-Based Microspheres for Ocular Delivery of Ketorolac Tromethamine: HET-CAM Test

Abstract

The present study was initiated with aim to fabricate ketorolac tromethamine loaded Tamarindus indica seed and Basella alba seed mucilage based alginate microspheres for ocular drug delivery. The ionotropic gelation method was used for preparation of drug loaded microspheres. The formulated mucilage-alginate based microspheres showed acceptable particle diameter and good stability as predicted from surface charge. The Tamarindus indica and Basella alba mucilage based microspheres revealed better swelling and mucoadhesive potential compared to both Tamarindus indica as well as Basella alba mucilage microspheres. All three formulation showed slow drug release for 12 hours in simulated tear fluid. In addition to this, the hen egg chorioallantoic membrane test revealed minimum irritation potential of formulation. Thus mucilage obtained from seeds of Tamarindus indica and Basella alba could be promising alternative for preparation of drug loaded microspheres.